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Issue 28, 2013
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A genetically active nano-calcium phosphate paste for bone substitution, encoding the formation of BMP-7 and VEGF-A

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Abstract

Calcium phosphate nanoparticles with different compositions and morphologies loaded with DNA were prepared. Plasmids which encoded either bone morphogenetic protein 7 (BMP-7) or vascular endothelial growth factor A (VEGF-A) were used for transfection in epithelial cells (HeLa), osteoblast-like cells (MG-63), and human mesenchymal stem cells (hMSC). In particular, cationic nanoparticles showed high transfection efficiency together with low cytotoxicity. The nanoparticles can either be used in dispersion or added to a calcium phosphate paste for injection into bone defects.

Graphical abstract: A genetically active nano-calcium phosphate paste for bone substitution, encoding the formation of BMP-7 and VEGF-A

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Publication details

The article was received on 22 Dec 2012, accepted on 30 Jan 2013 and first published on 31 Jan 2013


Article type: Paper
DOI: 10.1039/C3RA23450A
Citation: RSC Adv., 2013,3, 11155-11161
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    A genetically active nano-calcium phosphate paste for bone substitution, encoding the formation of BMP-7 and VEGF-A

    S. Chernousova, J. Klesing, N. Soklakova and M. Epple, RSC Adv., 2013, 3, 11155
    DOI: 10.1039/C3RA23450A

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