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Issue 28, 2013
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Scaffolds for bone tissue engineering: role of surface patterning on osteoblast response

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Abstract

The fabrication of tissue engineering scaffolds necessitates amalgamation of a multitude of attributes including a desirable porosity to encourage vascular invasion, desired surface chemistry for controlled deposition of calcium phosphate-based mineral as well as ability to support attachment, proliferation, and differentiation of lineage specific progenitor cells. Scaffold fabrication often includes additional surface treatments to bring about desired changes in the surface chemistry. In this perspective, this review documents the important natural and synthetic scaffolds fabricated for bone tissue engineering applications in tandem with the surface treatment techniques to maneuver the biocompatibility of engineered scaffolds. This review begins with a discussion on the fundamental concepts related to biocompatibility as well as the characteristics of the biological micro-environment. The primary focus is to discuss the effects of surface micro/nano patterning on the modulation of bone cell response. Apart from reviewing a host of experimental studies reporting the functionality of osteoblast-like bone cells and stem cells on surface modified or textured bioceramic/biopolymer scaffolds, theoretical insights to predict cell behavior on a scaffold with different topographical features are also briefly analyzed.

Graphical abstract: Scaffolds for bone tissue engineering: role of surface patterning on osteoblast response

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Publication details

The article was received on 13 Dec 2012, accepted on 19 Feb 2013 and first published on 21 Feb 2013


Article type: Review Article
DOI: 10.1039/C3RA23315D
Citation: RSC Adv., 2013,3, 11073-11094
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    Scaffolds for bone tissue engineering: role of surface patterning on osteoblast response

    J. Mitra, G. Tripathi, A. Sharma and B. Basu, RSC Adv., 2013, 3, 11073
    DOI: 10.1039/C3RA23315D

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