Issue 48, 2013
From the journal:

RSC Advances

Pd-catalysed amination on a soluble polymer support: arylation of anilines with PEG-supported aryl halides†

Luísa C. R. Carvalho,a   Marina J. Dias Pires,a   Eduarda Fernandesb  and  M. Manuel B. Marques*a  

* Corresponding authors

a Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal
E-mail: mmbmarques@fct.unl.pt
Fax: +351-21-294-8550

b REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal

Abstract

PEG supported aryl halides were found to serve as substrates for the Pd-catalysed N-arylation of several substituted anilines and alkyl amines under solventless conditions. Moreover, the Pd2dba3/XPhos catalyst system enabled the coupling reactions to take place smoothly with excellent yields under a low catalyst loading (1 mol% Pd and 3 mol% ligand).

Graphical abstract: Pd-catalysed amination on a soluble polymer support: arylation of anilines with PEG-supported aryl halides

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Article information

DOI
https://doi.org/10.1039/C3RA45177A
Article type
Communication
Submitted
17 Sep 2013
Accepted
28 Oct 2013
First published
28 Oct 2013

RSC Adv., 2013,3, 25711-25715

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Pd-catalysed amination on a soluble polymer support: arylation of anilines with PEG-supported aryl halides

L. C. R. Carvalho, M. J. Dias Pires, E. Fernandes and M. M. B. Marques, RSC Adv., 2013, 3, 25711 DOI: 10.1039/C3RA45177A

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