Unnatural triazolyl nucleoside stabilizes an abasic site containing DNA duplex equally as the stabilization of a natural A–T pair

Abstract

A better than reported abasic duplex stabilization was achieved with the novel triazolylphenanthrene nucleoside ^TPhenB_Do. The large surface area, polarizability and strong stacking propensity of triazolylphenanthrene play a major role in the thermal stabilization of the ^TPhenB_Do–Φ duplex comparable to that of a natural A–T pair via a strong intercalative stacking interaction.