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Issue 44, 2013
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Iodide-catalyzed amide synthesis from alcohols and amines

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Abstract

An efficient method to prepare amides by a cascade strategy was developed. Using nBu4NI or NaI as the catalyst and tert-butyl hydroperoxide as the oxidant, various alcohols reacted with N-hydroxysuccinimide or N-hydroxyphthalimide affording corresponding active esters in moderate to good yield. The resulting active esters were converted into amides smoothly in one pot.

Graphical abstract: Iodide-catalyzed amide synthesis from alcohols and amines

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Publication details

The article was received on 20 Jul 2013, accepted on 02 Sep 2013 and first published on 05 Sep 2013


Article type: Communication
DOI: 10.1039/C3RA43799J
Citation: RSC Adv., 2013,3, 21306-21310
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    Iodide-catalyzed amide synthesis from alcohols and amines

    G. Wang, Q. Yu, J. Wang, S. Wang, S. Chen and X. Yu, RSC Adv., 2013, 3, 21306
    DOI: 10.1039/C3RA43799J

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