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Issue 41, 2013
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Dual protection of amino functions involving Boc

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Abstract

Protecting groups play a pivotal role in the synthesis of multifunctional targets and as amino functions often occur in this context, issues related to their protection become prominent. Primary amines are unique because they can accommodate two such groups. This review highlights various aspects related to the synthesis, properties and applications of products containing one or two Boc-groups resulting from dual protection of amines and amides. Attention is directed towards cases of facilitated cleavage due to mutual interaction between two protecting groups on the same nitrogen.

Graphical abstract: Dual protection of amino functions involving Boc

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Publication details

The article was received on 13 Jun 2013, accepted on 16 Jul 2013 and first published on 17 Jul 2013


Article type: Review Article
DOI: 10.1039/C3RA42956C
Citation: RSC Adv., 2013,3, 18691-18697
  • Open access: Creative Commons BY license
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    Dual protection of amino functions involving Boc

    U. Ragnarsson and L. Grehn, RSC Adv., 2013, 3, 18691
    DOI: 10.1039/C3RA42956C

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