Issue 16, 2013
From the journal:

RSC Advances

In(OTf)3 catalyzed C3-benzylation of indoles with benzyl alcohols in water†

Lin Wu,a   Ran Jiang,b   Jin-Ming Yang,a   Shun-Yi Wang*b  and  Shun-Jun Ji*b  

* Corresponding authors

a Key Laboratory of Coastal Wetland Bioresources and Environmental Protection of Jiangsu Province, College of Chemistry and Chemical Engineering, Yancheng Teachers University, Yancheng, 224002, P. R. China

b Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China
E-mail: shunjun@suda.edu.cn
Fax: +86-512-65880305
Tel: +86-512-65880305

Abstract

A novel C3-benzylation of indoles through C–O bond activation of benzyl alcohols catalyzed by In(OTf)3 in water has been developed. The reactions proceed smoothly in presence of In(OTf)3 as the catalyst without the use of any bases, ligands or other additives to perform the desired product in moderate to excellent yields.

Graphical abstract: In(OTf)3 catalyzed C3-benzylation of indoles with benzyl alcohols in water

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Article information

DOI
https://doi.org/10.1039/C3RA40251G
Article type
Paper
Submitted
17 Jan 2013
Accepted
07 Feb 2013
First published
08 Feb 2013

RSC Adv., 2013,3, 5459-5464

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In(OTf)3 catalyzed C3-benzylation of indoles with benzyl alcohols in water

L. Wu, R. Jiang, J. Yang, S. Wang and S. Ji, RSC Adv., 2013, 3, 5459 DOI: 10.1039/C3RA40251G

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