Issue 2, 2013
From the journal:

RSC Advances

Highly enantioselective three-component Povarov reaction catalyzed by SPINOL-phosphoric acids†

Dan Huang,a   Fangxi Xu,a   Tao Chen,b   Yanguang Wanga  and  Xufeng Lin*a  

* Corresponding authors

a Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China
E-mail: lxfok@zju.edu.cn

b School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, Jiangsu, P. R. China

Abstract

Chiral SPINOL-phosphoric acids exhibited high activities and excellent diastereo- and enantioselectivities in the catalysis of the three-component Povarov reaction of benzyl N-vinylcarbamate, anilines and aldehydes with a catalyst loading of 5 mol%. The synthetic utility of this protocol was demonstrated by the asymmetric synthesis of enantioenriched benzo[e]indolizidine with excellent yield and excellent level of sterecontrol.

Graphical abstract: Highly enantioselective three-component Povarov reaction catalyzed by SPINOL-phosphoric acids

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Article information

DOI
https://doi.org/10.1039/C2RA22796G
Article type
Paper
Submitted
07 Nov 2012
Accepted
07 Nov 2012
First published
07 Nov 2012

RSC Adv., 2013,3, 573-578

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Highly enantioselective three-component Povarov reaction catalyzed by SPINOL-phosphoric acids

D. Huang, F. Xu, T. Chen, Y. Wang and X. Lin, RSC Adv., 2013, 3, 573 DOI: 10.1039/C2RA22796G

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