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Issue 17, 2013
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pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)

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Abstract

Hydrogels and nanogels made from partially hydrolyzed poly(2-ethyl-2-oxazoline) (PEtOx) were prepared by two different processes. First, both hydrogels and nanogels were made in dilute media in the presence of 1,6-hexanediol di-glycidyl ether (1) as the cross-linker. Alternatively, the PEtOx precursor was engineered into nanogels by an inverse w/o emulsion process. In the latter case, in addition to cross-linker 1, a cleavable cross-linker homologue (2), namely 1,6-hydroxyethyl disulfide-bis-di-glycidyl ether, was used to produce cleavable nanogels. The pH-responsiveness of all cross-linked PEtOx derivatives was demonstrated in an acidic environment, owing to the protonation of residual ethylene imine groups and/or tertiary amines formed during the cross-linking reaction. Nanogels derived from cross-linker 2 could readily be cleaved under a reducing environment, due to the presence of disulfide linkages at the cross-linking points.

Graphical abstract: pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)

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Publication details

The article was received on 27 May 2013, accepted on 21 Jun 2013 and first published on 24 Jun 2013


Article type: Paper
DOI: 10.1039/C3PY00685A
Citation: Polym. Chem., 2013,4, 4801-4808
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    pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)

    C. Legros, M. De Pauw-Gillet, K. C. Tam, S. Lecommmandoux and D. Taton, Polym. Chem., 2013, 4, 4801
    DOI: 10.1039/C3PY00685A

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