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Issue 5, 2014
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Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

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Abstract

We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50–100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.

Graphical abstract: Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

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Publication details

The article was received on 06 Sep 2013, accepted on 27 Sep 2013 and first published on 03 Oct 2013


Article type: Communication
DOI: 10.1039/C3PY01245J
Citation: Polym. Chem., 2014,5, 1581-1585
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    Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

    Q. Yin, R. Tong, L. Yin, T. M. Fan and J. Cheng, Polym. Chem., 2014, 5, 1581
    DOI: 10.1039/C3PY01245J

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