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Issue 5, 2013
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Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging

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Abstract

We designed and synthesized a gadolinium(III)-decorated hyperbranched polyglycerol with a fluorescent polyhedral oligomeric silsesquioxane core (POSS–HPG–Gd), and demonstrated its application as a single-molecular nanoprobe for fluorescence and magnetic resonance dual imaging. The nanoprobe exhibited a uniform size with a mean diameter of 6 ± 1 nm revealed by transmission electron microscopy. POSS–HPG–Gd showed absorption and emission maxima at 405 and 570 nm in water, respectively, with a quantum yield of 41 ± 1%. Fluorescence cell imaging by confocal laser scanning microscopy using MCF-7 cancer cells as a model cell line revealed that the nanoprobe had been successfully internalized into the cytoplasm with high brightness, low cytotoxicity and good photostability. Further magnetic resonance imaging study demonstrated that POSS–HPG–Gd can serve as a promising probe for fluorescence and magnetic resonance dual modal imaging.

Graphical abstract: Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging

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Publication details

The article was received on 09 Oct 2012, accepted on 25 Nov 2012 and first published on 26 Nov 2012


Article type: Paper
DOI: 10.1039/C2PY20837G
Citation: Polym. Chem., 2013,4, 1517-1524
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    Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging

    J. Liu, K. Li, J. Geng, L. Zhou, P. Chandrasekharan, C. Yang and B. Liu, Polym. Chem., 2013, 4, 1517
    DOI: 10.1039/C2PY20837G

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