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Issue 2, 2013
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Waterborne polymer nanogels non-covalently crosslinked by multiple hydrogen bond arrays

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Abstract

Synthetic colloidal hydrogel particles of sub-micron dimensions, often referred to as microgels and/or nanogels, generally consist of water-soluble polymers held together through chemical crosslinking by covalent bonds in order to preserve the distinct colloidal particle identity. Here we demonstrate the synthesis of non-covalently crosslinked nanogel particles in which the crosslinking through covalent bonds is replaced by physical crosslinking induced by strong self-complementary quadruple hydrogen bond interactions. The multiple hydrogen bond (MHB) arrays were introduced in the form of a 2-ureido-4[1H]pyrimidinone (UPy) functionalized polyethylene glycol methacrylate (PEGMA) comonomer, which was employed in the synthesis of colloidal nanogels made from N-isopropylacrylamide (NIPAm) or a mixture of 2-(2-methoxyethoxy)ethyl methacrylate and oligo(ethylene glycol) methacrylate (MEO2MA-co-OEGMA) following conventional free radical polymerization routes. The temperature-dependent swelling properties of the non-covalently crosslinked nanogels with differences in UPy loadings were studied, clearly demonstrating that MHB arrays can work as crosslinking moieties warranting the colloidal particle identity of the prepared hydrogels.

Graphical abstract: Waterborne polymer nanogels non-covalently crosslinked by multiple hydrogen bond arrays

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Publication details

The article was received on 06 Aug 2012, accepted on 31 Aug 2012 and first published on 31 Aug 2012


Article type: Paper
DOI: 10.1039/C2PY20615C
Citation: Polym. Chem., 2013,4, 387-392
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    Waterborne polymer nanogels non-covalently crosslinked by multiple hydrogen bond arrays

    Y. Chen, N. Ballard and S. A. F. Bon, Polym. Chem., 2013, 4, 387
    DOI: 10.1039/C2PY20615C

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