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Issue 1, 2013
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Biocompatible well-defined chromophorepolymer conjugates for photodynamic therapy and two-photon imaging

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Abstract

A versatile approach is introduced for the synthesis of well-defined, biocompatible conjugates combining two-photon chromophores and hydrophilic multifunctional polymers synthesized by RAFT controlled radical polymerization. As an illustration, two different classes of conjugates carrying multiple fluorophores (based on an anthracene moiety, Anth) or photosensitizers (based on a dibromobenzene moiety, DBB) along the polymer chain were elaborated for bioimaging and photodynamic therapy (PDT) applications, respectively. In both cases, the polymer greatly improved the solubility in biorelevant media as well as the cell uptake. Anth conjugates provided high quality fluorescence microscopy images using both one- and two-photon excitation. DBB conjugates potently induced the death of cancer cells upon photoactivation.

Graphical abstract: Biocompatible well-defined chromophore–polymer conjugates for photodynamic therapy and two-photon imaging

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Publication details

The article was received on 25 Jul 2012, accepted on 24 Aug 2012 and first published on 24 Aug 2012


Article type: Paper
DOI: 10.1039/C2PY20565C
Citation: Polym. Chem., 2013,4, 61-67
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    Biocompatible well-defined chromophorepolymer conjugates for photodynamic therapy and two-photon imaging

    C. Cepraga, T. Gallavardin, S. Marotte, P. Lanoë, J. Mulatier, F. Lerouge, S. Parola, M. Lindgren, P. L. Baldeck, J. Marvel, O. Maury, C. Monnereau, A. Favier, C. Andraud, Y. Leverrier and M. Charreyre, Polym. Chem., 2013, 4, 61
    DOI: 10.1039/C2PY20565C

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