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Issue 12, 2013
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Comparison of the photophysical properties of three phenothiazine derivatives: transient detection and singlet oxygen production

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Abstract

New methylene blue (NMB+) and methylene violet (MV) are known for their photosensitizing properties for singlet oxygen (1O2) generation upon visible-light irradiation, and various examples of their use in the photodynamic inactivation of microorganisms and for photomedicinal purposes have been reported. However, their photophysical properties have never been extensively and systematically analyzed and compared. In the current work, we studied their absorption and fluorescence behavior relative to their parent compound, methylene blue (MB+), detected the transient species generated upon excitation of the photosensitizers and determined their quantum yields of singlet oxygen production. We could measure very high quantum yields of singlet oxygen production for all the studied compounds. NMB+ appeared similar to MB+, even though it produces 1O2 much more efficiently, and was slightly influenced by the solvent. MV, in contrast, was much more sensitive to the chemical environment, and the transient species formed upon irradiation were different in methanol and acetonitrile. It appeared to be a very good singlet oxygen sensitizer, but the influence of the chemical environment should be carefully considered for any application. The comparative characterization of these sensitizers will represent a support for the determination and the understanding of the photochemical mechanisms occurring by using these phenothiazine dyes for various photobiological applications.

Graphical abstract: Comparison of the photophysical properties of three phenothiazine derivatives: transient detection and singlet oxygen production

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Publication details

The article was received on 25 Jul 2013, accepted on 11 Sep 2013 and first published on 11 Oct 2013


Article type: Paper
DOI: 10.1039/C3PP50246E
Citation: Photochem. Photobiol. Sci., 2013,12, 2160-2169
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    Comparison of the photophysical properties of three phenothiazine derivatives: transient detection and singlet oxygen production

    F. Ronzani, A. Trivella, E. Arzoumanian, S. Blanc, M. Sarakha, C. Richard, E. Oliveros and S. Lacombe, Photochem. Photobiol. Sci., 2013, 12, 2160
    DOI: 10.1039/C3PP50246E

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