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Issue 1, 2013
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Spectral effects of UV on psoriasis

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Abstract

Ultraviolet B (UVB) is a highly effective, relatively safe, affordable and widely used therapeutic option for moderate psoriasis. Several types of UVB lamp are available to treat psoriasis, both broadband and narrowband, allowing a choice of spectral emission. However despite years of clinical use, the mechanism of action of UVB in clearing psoriasis remained incompletely understood. Moreover, there has been little insight into how the relative effectiveness of different UVB wavelengths linked to the mechanism of action, although it is known that the action spectrum for clearance of psoriasis differs from the action spectrum of erythema. This paper examines the existing literature from which our current treatments have evolved, and offers new insight into the use of keratinocyte apoptosis as a biomarker which may help to optimise UV treatment in the future. When combined with a systems biology approach, this potential biomarker may provide insight into which wavelengths of UV are the most effective in clearing psoriasis, allowing a more rational and potentially an individually tailored approach to optimising phototherapy for psoriasis.

Graphical abstract: Spectral effects of UV on psoriasis

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Publication details

The article was received on 24 Apr 2012, accepted on 11 Sep 2012 and first published on 18 Sep 2012


Article type: Perspective
DOI: 10.1039/C2PP25116G
Citation: Photochem. Photobiol. Sci., 2013,12, 47-53
  • Open access: Creative Commons BY license
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    Spectral effects of UV on psoriasis

    S. C. Weatherhead, P. M. Farr and N. J. Reynolds, Photochem. Photobiol. Sci., 2013, 12, 47
    DOI: 10.1039/C2PP25116G

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