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Issue 35, 2013
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Chemical introduction of the green fluorescence: imaging of cysteine cathepsins by an irreversibly locked GFP fluorophore

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Abstract

An activity-based probe, containing an irreversibly locked GFP-like fluorophore, was synthesized and evaluated as an inhibitor of human cathepsins and, as exemplified with cathepsin K, it proved to be suitable for ex vivo imaging and quantification of cysteine cathepsins by SDS-PAGE.

Graphical abstract: Chemical introduction of the green fluorescence: imaging of cysteine cathepsins by an irreversibly locked GFP fluorophore

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Publication details

The article was received on 30 Jun 2013, accepted on 16 Jul 2013 and first published on 16 Jul 2013


Article type: Paper
DOI: 10.1039/C3OB41341A
Citation: Org. Biomol. Chem., 2013,11, 5913-5921
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    Chemical introduction of the green fluorescence: imaging of cysteine cathepsins by an irreversibly locked GFP fluorophore

    M. Frizler, I. V. Yampolsky, M. S. Baranov, M. Stirnberg and M. Gütschow, Org. Biomol. Chem., 2013, 11, 5913
    DOI: 10.1039/C3OB41341A

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