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Issue 32, 2013
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A fluorogenic assay for screening Sirt6 modulators

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Abstract

A fluorogenic high-throughput assay suitable for screening Sirt6 modulators is developed based on the recently discovered efficient activity of Sirt6 to hydrolyze myristoyl lysine. Sirt6 modulators will be useful in investigating the function of Sirt6 and protein lysine fatty acylation.

Graphical abstract: A fluorogenic assay for screening Sirt6 modulators

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Publication details

The article was received on 31 May 2013, accepted on 25 Jun 2013 and first published on 25 Jun 2013


Article type: Communication
DOI: 10.1039/C3OB41138A
Citation: Org. Biomol. Chem., 2013,11, 5213-5216
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    A fluorogenic assay for screening Sirt6 modulators

    J. Hu, B. He, S. Bhargava and H. Lin, Org. Biomol. Chem., 2013, 11, 5213
    DOI: 10.1039/C3OB41138A

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