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Issue 35, 2013
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KOtBu-mediated stereoselective addition of quinazolines to alkynes under mild conditions

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Abstract

A facile alkenylation of quinazolines with unactivated terminal alkynes has been achieved in the presence of KOtBu without the aid of any transition metal catalysts. The reaction is carried out under very mild conditions and shows a high stereoselectivity. A possible radical-based mechanism is also explored.

Graphical abstract: KOtBu-mediated stereoselective addition of quinazolines to alkynes under mild conditions

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Publication details

The article was received on 24 May 2013, accepted on 15 Jul 2013 and first published on 15 Jul 2013


Article type: Paper
DOI: 10.1039/C3OB41083H
Citation: Org. Biomol. Chem., 2013,11, 5908-5912
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    KOtBu-mediated stereoselective addition of quinazolines to alkynes under mild conditions

    D. Zhao, Q. Shen, Y. Zhou and J. Li, Org. Biomol. Chem., 2013, 11, 5908
    DOI: 10.1039/C3OB41083H

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