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Issue 34, 2013
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Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

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Abstract

The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.

Graphical abstract: Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

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Publication details

The article was received on 15 May 2013, accepted on 28 Jun 2013 and first published on 03 Jul 2013


Article type: Paper
DOI: 10.1039/C3OB41016A
Citation: Org. Biomol. Chem., 2013,11, 5702-5713
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    Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

    M. Dvorakova, R. Nencka, M. Dejmek, E. Zbornikova, A. Brezinova, M. Pribylova, R. Pohl, M. E. Migaud and T. Vanek, Org. Biomol. Chem., 2013, 11, 5702
    DOI: 10.1039/C3OB41016A

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