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Issue 29, 2013
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Various cyclization scaffolds by a truly Ugi 4-CR

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Abstract

Efficient access to a large chemical space based on new scaffolds with defined 3D conformations and highly variable in the side chains is needed to find novel functional materials. Four heterocyclic scaffolds based on a four component Ugi reaction of α-amino acids, oxo components, isocyanides and primary or secondary amines suitably functionalized are described. A handful of examples are described for each scaffold.

Graphical abstract: Various cyclization scaffolds by a truly Ugi 4-CR

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Publication details

The article was received on 14 Mar 2013, accepted on 17 May 2013 and first published on 20 May 2013


Article type: Paper
DOI: 10.1039/C3OB40523K
Citation: Org. Biomol. Chem., 2013,11, 4792-4796
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    Various cyclization scaffolds by a truly Ugi 4-CR

    M. K. Sinha, K. Khoury, E. Herdtweck and A. Dömling, Org. Biomol. Chem., 2013, 11, 4792
    DOI: 10.1039/C3OB40523K

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