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Issue 30, 2013
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Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group

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Abstract

A removable protecting group has been identified that allows the products of widely-used cross dehydrogenative couplings to be synthetically elaborated. The method can be used with enantiopure amines with no loss of enantiomeric excess. The methodology is exemplified by a new synthesis of enantiopure praziquantel, the drug used in the treatment of millions of people suffering from the neglected tropical disease, schistosomiasis.

Graphical abstract: Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group

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Publication details

The article was received on 12 Mar 2013, accepted on 18 Jun 2013 and first published on 19 Jun 2013


Article type: Communication
DOI: 10.1039/C3OB40503F
Citation: Org. Biomol. Chem., 2013,11, 4921-4924
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    Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group

    A. S.-K. Tsang, K. Ingram, J. Keiser, D. B. Hibbert and M. H. Todd, Org. Biomol. Chem., 2013, 11, 4921
    DOI: 10.1039/C3OB40503F

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