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Issue 25, 2013
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A squaraine-based red emission off–on chemosensor for biothiols and its application in living cells imaging

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Abstract

A new probe based on the squaraine skeleton with a 2,4-dinitrobenzenesulfonyl unit is reported as a fluorescent probe for biothiol. It shows turn-on properties with red emission towards biothiols in acetonitrilePBS buffer (1 : 9, v/v) solution, and its properties of rapid response, high selectivity and high sensitivity make it a potential probe with real applications. Moreover, the in vitro assays show that the probe can be used in fluorescence imaging for the detection of intracellular biothiol levels.

Graphical abstract: A squaraine-based red emission off–on chemosensor for biothiols and its application in living cells imaging

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Publication details

The article was received on 12 Mar 2013, accepted on 18 Apr 2013 and first published on 19 Apr 2013


Article type: Paper
DOI: 10.1039/C3OB40502H
Citation: Org. Biomol. Chem., 2013,11, 4258-4264
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    A squaraine-based red emission off–on chemosensor for biothiols and its application in living cells imaging

    X. Liu, R. Sun, J. Ge, Y. Xu, Y. Xu and J. Lu, Org. Biomol. Chem., 2013, 11, 4258
    DOI: 10.1039/C3OB40502H

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