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Issue 23, 2013
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N-(Guanidinoethyl)-2′-deoxy-5-methylisocytidine exhibits selective recognition of a CG interrupting site for the formation of anti-parallel triplexes

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Abstract

The development of novel nucleoside analogues for the formation of triplex DNA containing pyrimidinepurine inversion sites has been a challenging field. In this paper, we describe the design and synthesis of non-natural nucleoside analogues, N-substituted-2′-deoxy-5-methylisocytidine derivatives, and their evaluation for triplex formation. It has been shown that N-(guanidinoethyl)-2′-deoxy-5-methylisocytidine exhibits selective recognition of a CG interrupting site and potentiates the formation of anti-parallel triplexes.

Graphical abstract: N-(Guanidinoethyl)-2′-deoxy-5-methylisocytidine exhibits selective recognition of a CG interrupting site for the formation of anti-parallel triplexes

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Publication details

The article was received on 07 Mar 2013, accepted on 16 Apr 2013 and first published on 16 Apr 2013


Article type: Paper
DOI: 10.1039/C3OB40472B
Citation: Org. Biomol. Chem., 2013,11, 3918-3924
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    N-(Guanidinoethyl)-2′-deoxy-5-methylisocytidine exhibits selective recognition of a CG interrupting site for the formation of anti-parallel triplexes

    H. Okamura, Y. Taniguchi and S. Sasaki, Org. Biomol. Chem., 2013, 11, 3918
    DOI: 10.1039/C3OB40472B

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