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Issue 19, 2013
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Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties

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Abstract

A series of functionalized phenyl oxazole derivatives was designed, synthesized and screened in vitro for their activities against LSD1 and for effects on viability of cervical and breast cancer cells, and in vivo for effects using zebrafish embryos. These compounds are likely to act via multiple epigenetic mechanisms specific to cancer cells including LSD1 inhibition.

Graphical abstract: Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties

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Publication details

The article was received on 31 Jan 2013, accepted on 21 Mar 2013 and first published on 22 Mar 2013


Article type: Communication
DOI: 10.1039/C3OB40217G
Citation: Org. Biomol. Chem., 2013,11, 3103-3107
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    Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties

    B. Dulla, K. T. Kirla, V. Rathore, G. S. Deora, S. Kavela, S. Maddika, K. Chatti, O. Reiser, J. Iqbal and M. Pal, Org. Biomol. Chem., 2013, 11, 3103
    DOI: 10.1039/C3OB40217G

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