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Issue 19, 2013
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Gold amides as anticancer drugs: synthesis and activity studies

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Abstract

Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.

Graphical abstract: Gold amides as anticancer drugs: synthesis and activity studies

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Publication details

The article was received on 19 Dec 2012, accepted on 26 Mar 2013 and first published on 15 Apr 2013


Article type: Paper
DOI: 10.1039/C3OB27460H
Citation: Org. Biomol. Chem., 2013,11, 3255-3260
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    Gold amides as anticancer drugs: synthesis and activity studies

    S. Newcombe, M. Bobin, A. Shrikhande, C. Gallop, Y. Pace, H. Yong, R. Gates, S. Chaudhuri, M. Roe, E. Hoffmann and E. M. E. Viseux, Org. Biomol. Chem., 2013, 11, 3255
    DOI: 10.1039/C3OB27460H

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