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Issue 17, 2013
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Low-molecular-weight gelators consisting of hybrid cyclobutane-based peptides

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Abstract

Some hybrid tetrapeptides consisting of (1R,2S)-2-aminocyclobutane-1-carboxylic acid and glycine, β-alanine, or γ-aminobutyric acid (GABA) joined in alternation, compounds 1–3, respectively, have been investigated to gain information on the non-covalent interactions responsible for their self-assembly to form ordered aggregates, as well as on parameters such as their morphology and size. All three peptides formed nice gels in many organic solvents and significant difference in their behaviour was not observed. Scanning electron microscopy (SEM) and circular dichroism (CD) pointed out that peptide 1, which contains the shortest C2 linear residue, presented the most defined fibril network and afforded nanoscale helical aggregates. Tetrapeptide 3, with C4 linear residues in its structure, also showed bundles of fibres whereas a homogeneous spherulitic network was observed for tetrapeptide 2, with a C3 spacer between cyclobutane residues. Computational calculations for 1 allowed us to model the self-assembly of the molecules and suggested a head-to-head arrangement to give helical structures corresponding to hydrogen-bonded single chains. These features were corroborated by a high-resolution NMR spectroscopy study of the dynamics of the gelation process in toluene-d8 which evidenced that molecules self-assemble to afford ordered aggregates with a supramolecular chirality.

Graphical abstract: Low-molecular-weight gelators consisting of hybrid cyclobutane-based peptides

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Publication details

The article was received on 03 Dec 2012, accepted on 25 Feb 2013 and first published on 25 Feb 2013


Article type: Paper
DOI: 10.1039/C3OB27347D
Citation: Org. Biomol. Chem., 2013,11, 2839-2846
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    Low-molecular-weight gelators consisting of hybrid cyclobutane-based peptides

    S. Celis, P. Nolis, O. Illa, V. Branchadell and R. M. Ortuño, Org. Biomol. Chem., 2013, 11, 2839
    DOI: 10.1039/C3OB27347D

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