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Issue 8, 2013
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Efficient synthesis of silylated 2,2-difluorostyrene derivatives through Suzuki–Miyaura cross-coupling of 2,2-difluoro-1-iodo-1-silylethenes

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Abstract

We report a new synthetic sequence for the preparation of silylated 2,2-difluorostyrene derivatives. This new route has numerous advantages over the previous one including enhanced scope, higher yields, ease of purification, and significant reduction of the amount of desilylated side-products. An unexpected transformation of a silylated 2,2-difluorostyrene derivative is also presented.

Graphical abstract: Efficient synthesis of silylated 2,2-difluorostyrene derivatives through Suzuki–Miyaura cross-coupling of 2,2-difluoro-1-iodo-1-silylethenes

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Publication details

The article was received on 14 Nov 2012, accepted on 13 Dec 2012 and first published on 16 Jan 2013


Article type: Paper
DOI: 10.1039/C2OB27221K
Citation: Org. Biomol. Chem., 2013,11, 1367-1375
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    Efficient synthesis of silylated 2,2-difluorostyrene derivatives through Suzuki–Miyaura cross-coupling of 2,2-difluoro-1-iodo-1-silylethenes

    M. Turcotte-Savard and J. Paquin, Org. Biomol. Chem., 2013, 11, 1367
    DOI: 10.1039/C2OB27221K

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