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Issue 1, 2013
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Investigations regarding the utility of prodigiosenes to treat leukemia

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Abstract

Prodigiosenes, possessing a 4-methoxypyrrolyldipyrrin skeleton, are known for their anti-cancer activity. Structural modification of the C-ring resulted in a series of prodigiosenes that displayed promising activity against leukemia cell lines during in vitro analysis against the NCI 60 cancer cell line panel. Further in vivo studies of these compounds using the zebrafish model showed persistence of anti-leukemia properties in human K562 chronic myelogenous leukemia cells.

Graphical abstract: Investigations regarding the utility of prodigiosenes to treat leukemia

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Publication details

The article was received on 03 Aug 2012, accepted on 02 Oct 2012 and first published on 15 Oct 2012


Article type: Paper
DOI: 10.1039/C2OB26535D
Citation: Org. Biomol. Chem., 2013,11, 62-68
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    Investigations regarding the utility of prodigiosenes to treat leukemia

    D. A. Smithen, A. M. Forrester, D. P. Corkery, G. Dellaire, J. Colpitts, S. A. McFarland, J. N. Berman and A. Thompson, Org. Biomol. Chem., 2013, 11, 62
    DOI: 10.1039/C2OB26535D

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