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Copper(II)-catalyzed enantioselective hydrosilylation of halo-substituted alkyl aryl and heteroaryl ketones: asymmetric synthesis of (R)-fluoxetine and (S)-duloxetine

Ji-Ning Zhou,a   Qiang Fang,a   Yi-Hu Hu,a   Li-Yao Yang,a   Fei-Fei Wu,a   Lin-Jie Xie,a   Jing Wu*a and   Shijun Li*a  
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College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China
E-mail: jingwubc@hznu.edu.cn, l_shijun@hznu.edu.cn;
Fax: (+86)-571-2886-8023
Org. Biomol. Chem., 2014,12, 1009-1017

DOI: 10.1039/C3OB42214C
Received 08 Nov 2013, Accepted 03 Dec 2013
First published online 03 Dec 2013
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