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Issue 8, 2014
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Nickel-catalyzed triarylamine synthesis: synthetic and mechanistic aspects

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Abstract

An improved protocol was described for the amination of chloroarenes with diarylamines under NiCl2(PCy3)2 catalysis in the presence of a Grignard reagent as base. This method fully suits bromo-/iodoarene substrates as well, and even is expanded to certain aryl tosylates. A preliminary investigation into the mechanism suggests that this amination reaction might proceed through NiI and NiIII intermediates rather than via the usually expected Ni0–NiII cycle.

Graphical abstract: Nickel-catalyzed triarylamine synthesis: synthetic and mechanistic aspects

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Publication details

The article was received on 14 Oct 2013, accepted on 27 Nov 2013 and first published on 28 Nov 2013


Article type: Paper
DOI: 10.1039/C3OB42053A
Citation: Org. Biomol. Chem., 2014,12, 1232-1236
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    Nickel-catalyzed triarylamine synthesis: synthetic and mechanistic aspects

    X. Li, W. Wu, X. Fan and L. Yang, Org. Biomol. Chem., 2014, 12, 1232
    DOI: 10.1039/C3OB42053A

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