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Issue 2, 2014
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Chemoselective N-deacetylation under mild conditions

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A mild and efficient chemoselective N-deacetylation using the Schwartz reagent at room temperature in rapid time is described. The mild and neutral conditions enable orthogonal N-deacetylation in the presence of some of the common protecting groups (viz. Boc, Fmoc, Cbz, Ts). The deprotection conditions did not induce any epimerization at the chiral amino centre.

Graphical abstract: Chemoselective N-deacetylation under mild conditions

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The article was received on 29 Sep 2013, accepted on 28 Oct 2013, published on 29 Oct 2013 and first published online on 29 Oct 2013

Article type: Communication
DOI: 10.1039/C3OB41971A
Citation: Org. Biomol. Chem., 2014,12, 261-264
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    Chemoselective N-deacetylation under mild conditions

    P. R. Sultane, T. B. Mete and R. G. Bhat, Org. Biomol. Chem., 2014, 12, 261
    DOI: 10.1039/C3OB41971A

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