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Issue 1, 2014
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Asymmetric chroman synthesis via an intramolecular oxy-Michael addition by bifunctional organocatalysts

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Abstract

Cinchona-alkaloid-urea-based bifunctional organocatalysts facilitate the catalytic asymmetric synthesis of chroman derivatives via an intramolecular oxy-Michael addition reaction. Phenol derivatives bearing an easily available (E)-α,β-unsaturated ketone or a thioester moiety are useful substrates for the title transformation. This method represents a facile synthesis of various optically active 2-substituted chromans in high yield.

Graphical abstract: Asymmetric chroman synthesis via an intramolecular oxy-Michael addition by bifunctional organocatalysts

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Publication details

The article was received on 24 Sep 2013, accepted on 29 Oct 2013 and first published on 29 Oct 2013


Article type: Paper
DOI: 10.1039/C3OB41938J
Citation: Org. Biomol. Chem., 2014,12, 119-122
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    Asymmetric chroman synthesis via an intramolecular oxy-Michael addition by bifunctional organocatalysts

    R. Miyaji, K. Asano and S. Matsubara, Org. Biomol. Chem., 2014, 12, 119
    DOI: 10.1039/C3OB41938J

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