Jump to main content
Jump to site search

Issue 1, 2014
Previous Article Next Article

Chiral amides via copper-catalysed enantioselective conjugate addition

Author affiliations

Abstract

A highly enantioselective one pot procedure for the synthesis of β-substituted amides was developed starting from the corresponding α,β-unsaturated esters. This new methodology is based on the copper-catalysed enantioselective conjugate addition of Grignard reagents to α,β-unsaturated esters and subsequent direct formation of amides by quenching the corresponding enolates with different amines. Various primary and secondary amines bearing alkyl or aryl substituents can be used giving rise to a large variety of β-substituted amides with excellent enantioselectivities.

Graphical abstract: Chiral amides via copper-catalysed enantioselective conjugate addition

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 22 Sep 2013, accepted on 28 Oct 2013, published on 29 Oct 2013 and first published online on 29 Oct 2013


Article type: Communication
DOI: 10.1039/C3OB41923A
Citation: Org. Biomol. Chem., 2014,12, 36-41
  •   Request permissions

    Chiral amides via copper-catalysed enantioselective conjugate addition

    A. K. Schoonen, M. Á. Fernández-Ibáñez, M. Fañanás-Mastral, J. F. Teichert and B. L. Feringa, Org. Biomol. Chem., 2014, 12, 36
    DOI: 10.1039/C3OB41923A

Search articles by author