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Issue 43, 2013
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Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides

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Abstract

Structural investigations of peptides using NMR spectroscopy rarely include the detection of N–H⋯O[double bond, length as m-dash]C and N–H⋯N hydrogen bonds, because the relevant heteronuclei have a low natural abundance while the small trans hydrogen bond scalar couplings reduce the sensitivity. Fast repetition NMR techniques combined with state of the art spectrometer specifications allowed the enhancement of the sensitivity for detection of hydrogen bonds at natural isotopic abundance.

Graphical abstract: Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides

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Publication details

The article was received on 13 Sep 2013, accepted on 19 Sep 2013 and first published on 08 Oct 2013


Article type: Paper
DOI: 10.1039/C3OB41876F
Citation: Org. Biomol. Chem., 2013,11, 7611-7615
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    Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides

    A. Altmayer-Henzien, V. Declerck, D. J. Aitken, E. Lescop, D. Merlet and J. Farjon, Org. Biomol. Chem., 2013, 11, 7611
    DOI: 10.1039/C3OB41876F

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