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Issue 1, 2014
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Copper-catalyzed redox-neutral C–H amination with amidoximes

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Abstract

CuI-catalyzed reactions of N-alkylamidoximes afforded dihydroimidazoles via sp3 C–H amination. On the other hand, the reactions of N-benzoylamidoximes resulted in sp2 C–H amination to form quinazolinones. The reaction mechanisms could be characterized as a redox-neutral radical pathway including a Cu(I)–Cu(II) redox catalytic cycle.

Graphical abstract: Copper-catalyzed redox-neutral C–H amination with amidoximes

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Publication details

The article was received on 12 Sep 2013, accepted on 31 Oct 2013 and first published on 01 Nov 2013


Article type: Communication
DOI: 10.1039/C3OB41871E
Citation: Org. Biomol. Chem., 2014,12, 42-46
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    Copper-catalyzed redox-neutral C–H amination with amidoximes

    H. Chen and S. Chiba, Org. Biomol. Chem., 2014, 12, 42
    DOI: 10.1039/C3OB41871E

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