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Issue 3, 2014
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NBD-based colorimetric and fluorescent turn-on probes for hydrogen sulfide

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Abstract

Hydrogen sulfide (H2S) is an important endogenous signalling molecule and also an important environmental target for detection. New reaction-based colorimetric and fluorescent turn-on probes based on selective thiolyling of NBD (7-nitro-1,2,3-benzoxadiazole) ether were explored for sensing of H2S in aqueous buffer. The syntheses of both probes are simple and quite straightforward. The probes are highly sensitive and selective toward H2S over other biologically relevant species. Probe 1 can be used to directly visualize H2S by the naked eye and shows more than 1000-fold fluorescence increase upon reaction with H2S. Probe 2 is a near-infrared fluorescent sensor for H2S at physiological pH.

Graphical abstract: NBD-based colorimetric and fluorescent turn-on probes for hydrogen sulfide

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Publication details

The article was received on 12 Sep 2013, accepted on 29 Oct 2013 and first published on 29 Oct 2013


Article type: Paper
DOI: 10.1039/C3OB41870G
Citation: Org. Biomol. Chem., 2014,12, 479-485
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    NBD-based colorimetric and fluorescent turn-on probes for hydrogen sulfide

    C. Wei, Q. Zhu, W. Liu, W. Chen, Z. Xi and L. Yi, Org. Biomol. Chem., 2014, 12, 479
    DOI: 10.1039/C3OB41870G

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