Copper-catalyzed formation of N,N-dimethyl benzamide from nitrile and DMF under an O2 atmosphere†
Abstract
Amidation of nitrile with N,N-dimethylformamide (DMF) was catalyzed by Cu2O with 1,10-phenanthroline as a ligand under an oxygen atmosphere. A variety of N,N-dimethyl benzamides were obtained in yields up to 84%.