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Issue 1, 2014
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Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniae

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Abstract

Micacocidin is a promising natural product for the treatment of Mycoplasma pneumoniae infections. In the biosynthesis of this antibiotic, a fatty acid-AMP ligase (FAAL) activates the starter unit hexanoic acid as acyl-adenylate and forwards it to an iteratively acting polyketide synthase. Biochemical analysis of the FAAL revealed an extended substrate tolerance, thereby opening the door for the modification of a micacocidin residue that is barely accessible via semisynthesis. A total of six new analogues were generated by precursor-directed biosynthesis in this study and profiled against M. pneumoniae.

Graphical abstract: Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniae

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Publication details

The article was received on 09 Sep 2013, accepted on 25 Oct 2013 and first published on 31 Oct 2013


Article type: Paper
DOI: 10.1039/C3OB41839A
Citation: Org. Biomol. Chem., 2014,12, 113-118
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    Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniae

    M. F. Kreutzer, H. Kage, J. Herrmann, J. Pauly, R. Hermenau, R. Müller, D. Hoffmeister and M. Nett, Org. Biomol. Chem., 2014, 12, 113
    DOI: 10.1039/C3OB41839A

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