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Issue 42, 2013
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Dual-sugar imaging using isonitrile and azido-based click chemistries

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Abstract

We report the first account of metabolically labelling N-acetylglucosamine, in conjunction with either N-acetylgalactosamine or N-acetylmannosamine using a combination of isonitrile- and azide-based chemistries. With the appropriately labelled fluorescent probe molecules, that react with either the azido or isonitrile groups, the method enabled co-visualisation of cancer cell glycoproteins.

Graphical abstract: Dual-sugar imaging using isonitrile and azido-based click chemistries

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Publication details

The article was received on 23 Jul 2013, accepted on 13 Sep 2013 and first published on 16 Sep 2013


Article type: Paper
DOI: 10.1039/C3OB41805G
Citation: Org. Biomol. Chem., 2013,11, 7297-7300
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    Dual-sugar imaging using isonitrile and azido-based click chemistries

    Y. A. Wainman, A. A. Neves, S. Stairs, H. Stöckmann, H. Ireland-Zecchini, K. M. Brindle and F. J. Leeper, Org. Biomol. Chem., 2013, 11, 7297
    DOI: 10.1039/C3OB41805G

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