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Issue 43, 2013
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Is the 2,3-carbon–carbon bond of indole really inert to oxidative cleavage by Oxone? – Synthesis of isatoic anhydrides from indoles

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Abstract

A recent report has indicated that the oxidizing agent Oxone does not possess the ability to cleave the 2,3-carbon–carbon bond of indole. Work in our laboratory shows that this is not the case. Indole and a variety of aryl ring substituted derivatives readily react to form synthetically important isatoic anhydrides.

Graphical abstract: Is the 2,3-carbon–carbon bond of indole really inert to oxidative cleavage by Oxone? – Synthesis of isatoic anhydrides from indoles

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Publication details

The article was received on 04 Sep 2013, accepted on 24 Sep 2013 and first published on 03 Oct 2013


Article type: Communication
DOI: 10.1039/C3OB41802B
Citation: Org. Biomol. Chem., 2013,11, 7455-7457
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    Is the 2,3-carbon–carbon bond of indole really inert to oxidative cleavage by Oxone? – Synthesis of isatoic anhydrides from indoles

    A. C. Nelson, E. S. Kalinowski, N. J. Czerniecki, T. L. Jacobson and P. Grundt, Org. Biomol. Chem., 2013, 11, 7455
    DOI: 10.1039/C3OB41802B

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