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Issue 1, 2014
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To be or not to be metal-free: trends and advances in coupling chemistries

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Abstract

Coupling reactions have been part of several extensive studies in order to develop innovative and greener protocols that can generate a wide range of compounds with applications in pharmaceuticals, agrochemicals and biologically active compounds. Metal-free couplings are an important and increasingly trendy field that has attracted a significant deal of interest in recent years, generating a lot of controversy on the issue of whether metal free is really free. Aside from focusing on such a controversial topic itself, this contribution aims to provide a brief introduction on coupling chemistry to point out the transition of this technology from metal-catalyzed to metal-free. This is followed by a range of key selected synthetically useful metal-free processes and a brief commentary on the current debate of whether metal-free reactions are really metal-free and the required experiments for a full understanding of a metal-free coupling process.

Graphical abstract: To be or not to be metal-free: trends and advances in coupling chemistries

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Publication details

The article was received on 30 Aug 2013, accepted on 29 Oct 2013 and first published on 30 Oct 2013


Article type: Review Article
DOI: 10.1039/C3OB41768A
Citation: Org. Biomol. Chem., 2014,12, 10-35
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    To be or not to be metal-free: trends and advances in coupling chemistries

    R. A. D. Arancon, C. Sze Ki Lin, C. Vargas and R. Luque, Org. Biomol. Chem., 2014, 12, 10
    DOI: 10.1039/C3OB41768A

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