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Issue 4, 2014
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Design of an environmentally sensitive fluorescent 8-aza-7-deaza-2′-deoxyadenosine derivative with dual fluorescence for the specific detection of thymine

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Abstract

A novel environmentally sensitive fluorescent (ESF) purine nucleoside, cnaA, was synthesized and its photophysical properties were investigated. The base-modified fluorescent nucleoside cnaA exhibited remarkable solvatochromicity and environmentally sensitive dual fluorescence. By using cnaA, we have developed highly thymine (T) selective fluorescent DNA probes that can sense the corresponding T in a target DNA/RNA sequence, as measured by a distinct change in emission wavelength.

Graphical abstract: Design of an environmentally sensitive fluorescent 8-aza-7-deaza-2′-deoxyadenosine derivative with dual fluorescence for the specific detection of thymine

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Publication details

The article was received on 28 Aug 2013, accepted on 15 Oct 2013 and first published on 16 Oct 2013


Article type: Paper
DOI: 10.1039/C3OB41757C
Citation: Org. Biomol. Chem., 2014,12, 660-666
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    Design of an environmentally sensitive fluorescent 8-aza-7-deaza-2′-deoxyadenosine derivative with dual fluorescence for the specific detection of thymine

    A. Suzuki, N. Nemoto, I. Saito and Y. Saito, Org. Biomol. Chem., 2014, 12, 660
    DOI: 10.1039/C3OB41757C

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