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Issue 43, 2013
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Construction of the basic skeleton of ophiobolin A and variecolin

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Abstract

Ophiobolin and variecolin type sesterterpenoids belong to cyclooctane-containing natural products. Both sesterterpenoids have challenging structures and appealing biological activities. We envisioned that a key tandem ring closing metathesis of dienynes could provide the basic skeleton of ophiobolin A and variecolin. We report herein the detailed reactivities of the dienynes which furnished the 5-8-5 and 5-8-6-5 rings efficiently.

Graphical abstract: Construction of the basic skeleton of ophiobolin A and variecolin

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Publication details

The article was received on 19 Aug 2013, accepted on 10 Sep 2013 and first published on 11 Sep 2013


Article type: Paper
DOI: 10.1039/C3OB41693C
Citation: Org. Biomol. Chem., 2013,11, 7550-7558
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    Construction of the basic skeleton of ophiobolin A and variecolin

    K. Li, C. Wang, G. Yin and S. Gao, Org. Biomol. Chem., 2013, 11, 7550
    DOI: 10.1039/C3OB41693C

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