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Issue 42, 2013
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One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization

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Abstract

An efficient, one-pot synthesis of 4-methylisoquinolines via a cascade Pd-catalyzed Heck reaction, intramolecular cyclization and isomerization has been developed. This reaction has a wide range of substrates with various functional groups, and the corresponding products have been obtained in good yields.

Graphical abstract: One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization

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Publication details

The article was received on 16 Aug 2013, accepted on 13 Sep 2013 and first published on 13 Sep 2013


Article type: Communication
DOI: 10.1039/C3OB41680A
Citation: Org. Biomol. Chem., 2013,11, 7262-7266
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    One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization

    Y. Tian, J. Qi, C. Sun, D. Yin, X. Wang and Q. Xiao, Org. Biomol. Chem., 2013, 11, 7262
    DOI: 10.1039/C3OB41680A

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