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One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization

Yulin Tian,ab   Jianguo Qi,b   Chenbin Sun,b   Dali Yin,ab   Xiaojian Wang*ab and   Qiong Xiaob  
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a
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, P.R. China
E-mail: wangxiaojian@imm.ac.cn;
Fax: +86 10 63165248 ;
Tel: +86 10 63165248
b
Department of Medicinal Chemistry, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, P.R. China
Org. Biomol. Chem., 2013,11, 7262-7266

DOI: 10.1039/C3OB41680A
Received 16 Aug 2013, Accepted 13 Sep 2013
First published online 13 Sep 2013
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