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Issue 41, 2013
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Practical oxazole synthesis mediated by iodine from α-bromoketones and benzylamine derivatives

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Abstract

The reagent system of I2/K2CO3 could efficiently promote the oxazole synthesis from α-bromoketones and benzylamine derivatives in DMF. This method was not only suitable for 2,5-diaryl oxazole synthesis but also for 2,4,5-trisubstituted oxazole and 5-alkyl/alkenyl oxazole synthesis. Furthermore, this method was successfully applied to a one-step synthesis of a natural product halfordinol in 62% yield.

Graphical abstract: Practical oxazole synthesis mediated by iodine from α-bromoketones and benzylamine derivatives

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Publication details

The article was received on 31 Jul 2013, accepted on 30 Aug 2013 and first published on 30 Aug 2013


Article type: Paper
DOI: 10.1039/C3OB41566J
Citation: Org. Biomol. Chem., 2013,11, 7123-7128
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    Practical oxazole synthesis mediated by iodine from α-bromoketones and benzylamine derivatives

    W. Gao, R. Wang and C. Zhang, Org. Biomol. Chem., 2013, 11, 7123
    DOI: 10.1039/C3OB41566J

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