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Issue 32, 2013
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An approach to hyperolactone C and analogues using late stage conjugate addition on an oxonium ylide-derived spirofuranone

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Abstract

A stereocontrolled synthesis of norphenyl hyperolactone C together with its utility as a direct precursor to the anti-HIV agent hyperolactone C and analogues by addition of organolithiums, are described. Preliminary studies to access this key building block in a catalytic enantioselective manner are also reported.

Graphical abstract: An approach to hyperolactone C and analogues using late stage conjugate addition on an oxonium ylide-derived spirofuranone

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Publication details

The article was received on 18 Jun 2013, accepted on 20 Jun 2013 and first published on 12 Jul 2013


Article type: Paper
DOI: 10.1039/C3OB41251B
Citation: Org. Biomol. Chem., 2013,11, 5362-5369
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    An approach to hyperolactone C and analogues using late stage conjugate addition on an oxonium ylide-derived spirofuranone

    D. M. Hodgson, E. Moreno-Clavijo, S. E. Day and S. Man, Org. Biomol. Chem., 2013, 11, 5362
    DOI: 10.1039/C3OB41251B

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