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Issue 30, 2013
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Extending the range of supercritical fluid chromatography by use of water-rich modifiers

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Abstract

In this study we investigate the recently reported use of water-containing modifiers for separation and purification of hydrophilic compounds by supercritical fluid chromatography. Improved peak shape is obtained for a variety of glycosides and otherwise hydrophilic compounds when 5% water is added to the methanol co-solvent used in SFC separations, and examples of the use of this approach in preparative SFC purifications are presented.

Graphical abstract: Extending the range of supercritical fluid chromatography by use of water-rich modifiers

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Publication details

The article was received on 29 May 2013, accepted on 12 Jun 2013 and first published on 13 Jun 2013


Article type: Communication
DOI: 10.1039/C3OB41121D
Citation: Org. Biomol. Chem., 2013,11, 4925-4929
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    Extending the range of supercritical fluid chromatography by use of water-rich modifiers

    J. Liu, E. L. Regalado, I. Mergelsberg and C. J. Welch, Org. Biomol. Chem., 2013, 11, 4925
    DOI: 10.1039/C3OB41121D

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