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Issue 30, 2013
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Transition metal free hydrolysis/cyclization strategy in a single pot: synthesis of fused furo N-heterocycles of pharmacological interest

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Abstract

A transition metal free tandem two-step strategy has been developed involving hydrolysis of 2-chloro-3-alkynyl quinoxalines/pyrazines followed by in situ cyclization of the corresponding 2-hydroxy-3-alkynyl intermediates in a single pot leading to fused furo N-heterocycles as potential inhibitors of sirtuins. A representative compound showed promising pharmacological properties in vitro and in vivo.

Graphical abstract: Transition metal free hydrolysis/cyclization strategy in a single pot: synthesis of fused furo N-heterocycles of pharmacological interest

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Publication details

The article was received on 23 May 2013, accepted on 17 Jun 2013 and first published on 18 Jun 2013


Article type: Communication
DOI: 10.1039/C3OB41069B
Citation: Org. Biomol. Chem., 2013,11, 4930-4934
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    Transition metal free hydrolysis/cyclization strategy in a single pot: synthesis of fused furo N-heterocycles of pharmacological interest

    A. Nakhi, Md. S. Rahman, G. P. K. Seerapu, R. K. Banote, K. L. Kumar, P. Kulkarni, D. Haldar and M. Pal, Org. Biomol. Chem., 2013, 11, 4930
    DOI: 10.1039/C3OB41069B

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