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Issue 34, 2013
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Synthesis of human growth hormone-releasing hormone via three-fragment serine/threonine ligation (STL)

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Abstract

The synthesis of human growth hormone-releasing hormone (hGH-RH), by the chemoselective serine/threonine ligations (STLs) of three unprotected peptide fragments, is reported. To allow for the multiple-fragment ligation, we chose the Msz (p-(methylsulfinyl)benzyloxycarbonyl) group, which is compatible with the preparation of peptide salicylaldehyde esters via Fmoc-SPPS and readily removed by reductive acidolysis, to protect the serine and threonine residue at the N-terminus.

Graphical abstract: Synthesis of human growth hormone-releasing hormone via three-fragment serine/threonine ligation (STL)

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Publication details

The article was received on 17 May 2013, accepted on 09 Jul 2013 and first published on 10 Jul 2013


Article type: Communication
DOI: 10.1039/C3OB41027G
Citation: Org. Biomol. Chem., 2013,11, 5584-5587
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    Synthesis of human growth hormone-releasing hormone via three-fragment serine/threonine ligation (STL)

    Y. Zhang, T. Li and X. Li, Org. Biomol. Chem., 2013, 11, 5584
    DOI: 10.1039/C3OB41027G

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