Issue 34, 2013
From the journal:

Organic & Biomolecular Chemistry

Synthesis of human growth hormone-releasing hormonevia three-fragment serine/threonine ligation (STL)†

Yinfeng Zhang,a   Tianlu Lia  and  Xuechen Li*a  

* Corresponding authors

a Department of Chemistry, The University of Hong Kong, Hong Kong, P. R. China
E-mail: xuechenl@hku.hk
Fax: +86 85228571586

Abstract

The synthesis of human growth hormone-releasing hormone (hGH-RH), by the chemoselective serine/threonine ligations (STLs) of three unprotected peptide fragments, is reported. To allow for the multiple-fragment ligation, we chose the Msz (p-(methylsulfinyl)benzyloxycarbonyl) group, which is compatible with the preparation of peptide salicylaldehyde esters via Fmoc-SPPS and readily removed by reductive acidolysis, to protect the serine and threonine residue at the N-terminus.

Graphical abstract: Synthesis of human growth hormone-releasing hormone via three-fragment serine/threonine ligation (STL)

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Article information

DOI
https://doi.org/10.1039/C3OB41027G
Article type
Communication
Submitted
17 May 2013
Accepted
09 Jul 2013
First published
10 Jul 2013

Org. Biomol. Chem., 2013,11, 5584-5587

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Synthesis of human growth hormone-releasing hormone via three-fragment serine/threonine ligation (STL)

Y. Zhang, T. Li and X. Li, Org. Biomol. Chem., 2013, 11, 5584 DOI: 10.1039/C3OB41027G

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